Nolvadex® (tamoxifen citrate)

Tamoxifen citrate (Nolvadex) tablets USP, a nonsteroidal antiestrogen, are for oral administration.A synthetic nonsteroidal estrogen antagonist used in the prevention and treatment of breast cancer. Tamoxifen citrate tablets are available as:10 mg Tablets. Each tablet contains 15.2 mg of Tamoxifen citrate which is equivalent to 10 mg of Tamoxifen.20 mg Tablets. Each tablet contains 30.4 mg of Tamoxifen citrate which is equivalent to 20 mg of Tamoxifen.Each tablet contains the following inactive ingredients: carboxymethylcellulose calcium, magnesium stearate, mannitol and starch.Chemically, Tamoxifen is the trans-isomer of a triphenylethylene derivative.

Nolvadex, an anticancer drug, is given to treat breast cancer. It also has proved effective when cancer has spread to other parts of the body. Nolvadex is most effective in stopping the kind of breast cancer that thrives on estrogen.

Nolvadex is also prescribed to reduce the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. The drug can also be used to reduce the odds of breast cancer in women at high risk of developing the disease. It does not completely eliminate your chances, but in a five-year study of over 1,500 high-risk women, it slashed the number of cases by 44 percent.

Although Nolvadex reduces the risk of breast cancer, it increases othe possibility of developing endometrial (uterine) cancer. Women taking Nolvadex should have routine gynecological examinations and report any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure to the doctor immediately. Even after Nolvadex therapy has stopped, any abnormal vaginal bleeding should be reported at once.